Arranging eukaryotic nuclear DNA polymerases for replication
نویسندگان
چکیده
منابع مشابه
DNA polymerases that propagate the eukaryotic DNA replication fork.
Three DNA polymerases are thought to function at the eukaryotic DNA replication fork. Currently, a coherent model has been derived for the composition and activities of the lagging strand machinery. RNA-DNA primers are initiated by DNA polymerase ot-primase. Loading of the proliferating cell nuclear antigen, PCNA, dissociates DNA polymerase ca and recruits DNA polymerase S and the flap endonucl...
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Themajor function ofDNApolymerases is to replicate the genome and thus to allow transmission of genetic information fromone generation to the next. In eukaryotic cells, this takes place during a discrete period (S phase) of interphase, and replicated chromosomes are subsequently segregated to daughter cells during mitosis. As well as replicating DNA, polymerases help to maintain the integrity o...
متن کاملEukaryotic DNA polymerases.
Any living cell is faced with the fundamental task of keeping the genome intact in order to develop in an organized manner, to function in a complex environment, to divide at the right time, and to die when it is appropriate. To achieve this goal, an efficient machinery is required to maintain the genetic information encoded in DNA during cell division, DNA repair, DNA recombination, and the by...
متن کاملNomenclature of Eukaryotic DNA Polymerases
vious experiment (Table 1). It could be argued that after a nearly complete depletion of norepinephrine an additional small and undetectable decrease in norepinephrine might surpass some critical threshold and lead to the release of eating. However, if this were true we would also expect this threshold would have been surpassed in at least some of the more than 150 rats in our laboratory which ...
متن کاملSubunits shared by eukaryotic nuclear RNA polymerases.
RNA polymerases I, II, and III share three subunits that are immunologically and biochemically indistinguishable. The Saccharomyces cerevisiae genes that encode these subunits (RPB5, RPB6, and RPB8) were isolated and sequenced, and their transcriptional start sites were deduced. RPB5 encodes a 25-kD protein, RPB6, an 18-kD protein, and RPB8, a 16-kD protein. These genes are single copy, reside ...
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ژورنال
عنوان ژورنال: BioEssays
سال: 2017
ISSN: 0265-9247
DOI: 10.1002/bies.201700070